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When public refer to today’s medicine, accuracy plays one of the most significant roles and human lives are directly dependent on it. Hereby, any researches related to medicine are required to comply with the top standards. The issue nowadays is that any conclusions of researches can be shared online and used as a reference without being properly checked and validated. Mikhail (Misha) Blagosklonny of Oncotarget perfectly understood this issue and tried to come up with an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been founded back in 2010. The main principle of this journal is related to Altmetric scores that are used as a quality indicator. That helps both readers and authors to verify publications with Altmetric Article Reports that generate “real-time feedback containing data summary related to a particular publication". Oncotarget website has a complete publications list with corresponding scores higher than 100 as we...

  Oncotarget   Volume 11 ,   Issue 30   reported that recent evidence shows that the host innate immunity is also critical in sensing the presence of cytoplasmic DNA derived from genomic instability events, such as DNA damage and defective cell cycle progression. This is achieved through the cyclic GMP-AMP synthase /Stimulator of interferon genes pathway. Here the Oncotarget authors discuss recent insights into the regulation of this pathway in cancer immunosurveillance, and the downstream signaling cascades that coordinate immune cell recruitment to the tumor microenvironment to destroy transformed cells through cellular senescence or cell death programs. Its central role in immunosurveillance positions the cGAS-STING pathway as an attractive anti-cancer immunotherapeutic drug target for chemical agonists or vaccine adjuvants and suggests a key node to be targeted in a synthetic lethal approach. They also discuss adaptive mechanisms used by cancer cells to circumve...

When people discuss today’s medicine, accuracy plays one of the most crucial roles and people’s lives are literally dependent on it. Hereby, any researches related to medicine are required to meet the highest standards. The issue today is that any outcomes of researches can be published online and used as a reference without being properly checked and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this issue and tried to develop an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been founded back in 2010. The key principle of this journal is based on Altmetric scores that are used as a quality indicator. That allows both readers and authors to validate publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication". Oncotarget website demonstrates a full publications list with respective scores above 100 as well as reports menti...

  The cover for issue 35 of Oncotarget features Figure 4, "The in vivo pre- or post- topical application of BAY 11-7082 prevents the acidic bile-induced deregulation of cancer-related miRNA markers in 10-day exposed murine HM," by Vageli, et al. reported that Supraesophageal bile reflux at strongly acidic pH can cause hypopharyngeal squamous cell cancer, through activation of the oncogenic NF-κB-related pathway. The authors hypothesize that topical pre- or post-application of pharmacologic NF-κB inhibitor, BAY 11-7082, on murine HM can effectively inhibit acidic bile induced oncogenic molecular events, similar to prior in vitro findings. They demonstrate that the administration of BAY 11-7082, either before or after acidic bile, eliminates NF-κB activation, prevents overexpression of Bcl2, Rela, Stat3, Egfr, Tnf, Wnt5a, and deregulations of miR-192, miR-504, linked to bile reflux-related hypopharyngeal cancer. Pre- but not post-application of NF-κB inhibitor, significantly ...

When people speak of contemporary medicine, precision plays one of the most important roles and people’s lives are directly dependent on it. Hereby, any researches related to medicine are required to comply with the top standards. The challenge today is that any results of researches can be posted online and used as a reference without being thoroughly checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this challenge and decided to generate an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been founded back in 2010. The key principle of this journal is related to Altmetric scores that are used as a quality measure. That assists both readers and authors to validate publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication". Oncotarget website demonstrates a full publications list with corresponding scores above 100 a...

When public discuss today’s medicine, accuracy plays one of the most significant roles and human lives are literally dependent on it. Hereby, any researches related to medicine are required to meet the highest standards. The issue nowadays is that any outcomes of researches can be posted online and used as a reference without being thoroughly checked and validated. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this challenge and decided to create an alternative solution. That’s how a weekly oncology-focused research journal called “Oncotarget” has been founded back in 2010. The major principle of this journal is based on Altmetric scores that are used as a quality measure. That helps both readers and authors to verify publications with Altmetric Article Reports that provide “real-time feedback containing data summary related to a particular publication". Oncotarget website demonstrates a full publications list with respective scores higher than 100 as well as r...

  Oncotarget   recently published " Neuroendocrine carcinoma of uterine cervix findings shown by MRI for staging and survival analysis – Japan multicenter study " which reported that to investigate   neuroendocrine carcinoma   of the uterine cervix cases for MRI features and staging, as well as pathological correlations and survival. In 50 patients who underwent a radical hysterectomy and lymphadenectomy without neoadjuvant chemotherapy, intrapelvic T staging by MRI overall accuracy was 88.0% with reference to pathology staging, while patient-based sensitivity, specificity, and accuracy for metastatic pelvic lymph node detection was 38.5%, 100%, and 83.3%, respectively. Three-year progression-free and overall survival rates for FIGO I, II, III, and IV were 64.3% and 80.9%, 50% and 64.3%, 0% and 0%, and 0% and 0%, respectively. Sixty-two patients with histologically surgery-proven uterine cervical NEC were enrolled. The Oncotarget author's findings show that MRI is re...

When general population discuss contemporary medicine, accuracy plays one of the most important roles and human lives are directly dependent on it. Hence, any researches related to medicine are required to comply with the highest standards. The issue today is that any recommendations of researches can be shared online and used as a reference without being adequately verified and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this challenge and attempted to generate an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The major principle of this journal is related to Altmetric scores that are used as a quality measure. That assists both readers and authors to quality-check publications with Altmetric Article Reports that provide “real-time feedback containing data summary related to a particular publication". Oncotarget website has a complete publications list with correspon...

Oncotarget недавно опубликовал статью « Гетерогенность CEACAM5 при раке груди », в которой сообщается, что здесь мы исследовали репозиторий из 110 криоконсервированных первичных карцином груди с помощью иммуногистохимии, чтобы оценить распределение CEACAM5 по подтипам опухоли. Оценка наборов образцов парного первичного рака молочной железы и соответствующих поражений лимфатических узлов от всего 59 пациентов выявила высокую корреляцию между первичной опухолью и лимфатическим узлом в отношении CEACAM5-статуса. При изучении последствий экспрессии CEACAM5 в клеточных линиях рака груди в анализах культур мы обнаружили, что клетки, экспрессирующие CEACAM5, были менее инвазивными. При анализе выживаемости с использованием когортных исследований рака молочной железы экспрессия CEACAM5 предсказывала различные клинические исходы в зависимости от молекулярных подтипов. В целом, наш анализ показывает, что CEACAM5 играет контекстно-зависимую роль при раке груди, что требует дальнейшего иссле...

When people speak of modern medicine, accuracy plays one of the most important roles and human lives are directly dependent on it. Likewise, any researches pertaining to medicine are necessary to meet the top standards. The issue today is that any conclusions of researches can be shared online and used as a reference without being adequately checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this issue and attempted to develop an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The key principle of this journal is based on Altmetric scores that are used as a quality measure. That allows both readers and authors to quality-check publications with Altmetric Article Reports that create “real-time feedback containing data summary related to a particular publication". Oncotarget website demonstrates a full publications list with corresponding scores above 100 as well as...

When people mention modern medicine, precision plays one of the most crucial roles and human lives are literally dependent on it. Likewise, any researches related to medicine are necessary to meet the top standards. The problem nowadays is that any results of researches can be shared online and used as a reference without being precisely checked and approved. Mikhail (Misha) Blagosklonny of Oncotarget clearly understood this challenge and tried to generate an alternative solution. That’s how a weekly oncology-focused research journal named “Oncotarget” has been established back in 2010. The key principle of this journal is based on Altmetric scores that are used as a quality measure. That assists both readers and authors to validate publications with Altmetric Article Reports that generate “real-time feedback containing data summary related to a particular publication". Oncotarget website provides a full publications list with corresponding scores higher than 100 as well as re...